Pierced Lasso Bundles Are a New Class of Knot-like Motifs
Figure 3
Schematic view of the helical cytokine sub-family.
The cytokine sub-family (red) is divided into three families: The long-chain helical cytokines (pink), the short-chain helical cytokines (orange) and interferons/interleukin 10 (yellow). The overall topology within the cytokines is conserved with differences in length and topology, where the interferons and interleukin 10 have two extra helices outside the four-helix bundle and the long-chain and short-chain helical cytokines have one extra helix. The figure shows the proteins discussed in the text, where threaded motifs (PLBs) are circled and unthreaded proteins are boxed. We note that there are many unthreaded examples as well as a few PLB proteins in each family, not shown in this figure.