Mechanistic, Mathematical Model to Predict the Dynamics of Tissue Genesis in Bone Defects via Mechanical Feedback and Mediation of Biochemical Factors
Figure 11
Increasing the rate of consumption of BMP by chondrocytes and osteoblasts results in negative values for BMP, which is not physiologically plausible. A decrease in leaves considerably more BMP in the defect space, but does not notably alter ECM production as the processes are likely saturated.