Mechanistic, Mathematical Model to Predict the Dynamics of Tissue Genesis in Bone Defects via Mechanical Feedback and Mediation of Biochemical Factors
Figure 7
Increasing the rate of differentiation of progenitor cells to chondrocytes increases the density of chondrocytes and contributes to a more rapid consumption of BMP. Increased area fraction of cartilage is produced slightly sooner, indicative of more rapid tissue genesis.