Combined Role of Seizure-Induced Dendritic Morphology Alterations and Spine Loss in Newborn Granule Cells with Mossy Fiber Sprouting on the Hyperexcitability of a Computer Model of the Dentate Gyrus
Figure 5
Overall frequency of the network (total spike count over simulation time) for the different network families as a function of the proportion of newborn GCs.
All cases are for 10% of mossy fiber sprouting. Each point in the graph corresponds to an average over 20 randomly generated models of the corresponding family. The different network families are indicated by different colors and their codes are the same as defined in Table 2. A. Cases in which spine loss was represented by a 50% reduction in the probability of connections with newborn GCs. The MPSL1 network type only had results up to the insertion of 80% of newborn cells because the insertions of 90% and 100% of newborn GCs did not allow the maintenance of the convergence and divergence factors of the network. The error bars represent the standard error. The overall frequency is significantly different over the different proportions () and types of altered cells and spine loss inserted (
) and their interaction (
). B. Cases in which spine loss was represented by a reduction of 25%, 50% and 75% in the probability of newborn GCs receiving connections. The coding is the same as in A but followed by the corresponding reduction in the probability of connection.