Combined Role of Seizure-Induced Dendritic Morphology Alterations and Spine Loss in Newborn Granule Cells with Mossy Fiber Sprouting on the Hyperexcitability of a Computer Model of the Dentate Gyrus
Figure 4
Examples of raster plots for different DG network models.
A. Response of a mature network without mossy fiber sprouting. B. Response of a mature network with 10% mossy fiber sprouting. C. Response of a mature network with 50% mossy fiber sprouting. D. Response of a mature network with 50% newborn control GCs without mossy fiber sprouting. E. Response of a mature network with 10% newborn control GCs and 10% mossy fiber sprouting. F. Response of a mature network with 50% newborn control GCs and 10% mossy fiber sprouting. G. Response of a mature network with 50% newborn PILO GCs without mossy fiber sprouting. H. Response of a mature network with 10% newborn PILO GCs and 10% mossy fiber sprouting. I. Response of a mature network with 50% newborn PILO GCs and 10% mossy fiber sprouting. J. Response of a mature network with 10% newborn PILO GCs with spine loss and without mossy fiber sprouting. K. Response of a mature network with 10% newborn PILO GCs with spine loss and 10% mossy fiber sprouting. L. Response of a mature network with 50% newborn PILO GCs with spine loss and 10% mossy fiber sprouting. The latter three figures for the cases with spine loss were obtained for the SL2 case.