Combined Role of Seizure-Induced Dendritic Morphology Alterations and Spine Loss in Newborn Granule Cells with Mossy Fiber Sprouting on the Hyperexcitability of a Computer Model of the Dentate Gyrus
Figure 3
Comparison of the intrinsic excitability of the mature and newborn GCs from control (YOUNG) and PILO groups.
The cases for model cells without spine loss are indicated in blue and the cases for model cells with spine loss are indicated in red. A. Average rheobase current (measured as explained in the text) for the three model cell groups. B. Average number of spikes evoked by the train of synaptic-like pulses as explained in the text.