Combined Role of Seizure-Induced Dendritic Morphology Alterations and Spine Loss in Newborn Granule Cells with Mossy Fiber Sprouting on the Hyperexcitability of a Computer Model of the Dentate Gyrus
Figure 1
Scheme of the structure and topology of the network.
A. Schematic representation of network connections between granule cells (GC), basket cells (BC), hilar perforant-path associated cells (HC) and mossy cells (MC). GC synapses are indicated by black lines, BC synapses are indicated by blue lines, HC synapses are indicated by orange dashed lines and MC synapses are indicated by green lines. Mossy fiber sprouting (MFS) is indicated by a black dashed line and the perforant-path input to GC and BC is indicated by a bold black line. The segments into which the GC dendritic tree are divided are indicated in yellow (granule cell layer dendrites), orange (proximal dendrites), green (medial dendrites) and blue (distal dendrites). B. Positioning of the GC within the molecular layer with its four subdivisions: granular layer (GL) in blue, inner molecular layer (IML) in orange, middle molecular layer (MML) in green and outer molecular layer (OML) in blue. The figure shows that perforant-path synapses to GCs are located in OML dendrites and mossy fiber sprouting synapses to GCs are located in IML dendrites regardless of the type of dendritic segment in these layers. C. Schematic representation of the dentate gyrus model with control GCs. D. Schematic representation of the dentate gyrus model with a fraction of the control GCs replaced with cells from PILO-treated animals (in red).