Determining Effects of Non-synonymous SNPs on Protein-Protein Interactions using Supervised and Semi-supervised Learning
Figure 3
Snapshots of SNPIN-tool server.
Snapshots of the result visualization page of SNPIN-tool web server, freely available at http://korkinlab.org/snpintool/. The submission page allows users to upload a pdb file of the PPI structure and specify interacting chains with a mutation (nsSNP). When the submitted job is finished, SNPIN-tool returns the prediction results and the estimated likelihoods for the 2-class and 3-class classifiers. In addition, 3D structures of both wild-type and mutant PPIs with the highlighted residue position where nsSNP occurred are visualized.