Glutamate-Bound NMDARs Arising from In Vivo-like Network Activity Extend Spatio-temporal Integration in a L5 Cortical Pyramidal Cell Model
Figure 2
Background excitatory input reduces the number of nearly synchronously stimulated branches required to trigger action potentials.
(A) Somatic voltage response to the activation of 4 apical branches stimulated with 30 nearly synchronous synapses each, in the absence (black) and presence (blue) of 1500 background excitatory synapses distributed on the apical tuft. (B) Probability of triggering action potentials (P(AP)) versus number of stimulated branches, in the absence (black open circles) and presence of different levels of background excitation (blue filled circles). Lines show fits to a sigmoid function. Grey line and circles show results for 15 synaptic inputs per branch and 1500 background excitatory synapses.