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Mathematical Modeling Reveals Kinetics of Lymphocyte Recirculation in the Whole Organism

Figure 1

Two types of experiments performed in rats by Smith & Ford [65].

In the first set of experiments (migration data, panel A), thoracic duct lymphocytes (TDLs) were collected overnight from male donor rats by cannulation and labeled with sodium-[Cr] chromate. Labeled lymphocytes were passaged from blood to lymph in vivo by thoracic duct cannulation in an intermediate male. Collected lymphocytes were injected into female recipient rats and the percent of injected donor lymphocytes was measured in major lymphoid and nonlymphoid organs of the recipient rats. In the second set of experiments (cannulation data, panel B), TDLs were passaged via an intermediate host and then injected into the final recipients. Donor lymphocytes were counted during the thoracic duct cannulation of the recipient rats over the period of 45 hours.

doi: https://doi.org/10.1371/journal.pcbi.1003586.g001