Interplay of Intrinsic and Synaptic Conductances in the Generation of High-Frequency Oscillations in Interneuronal Networks with Irregular Spiking

doi:10.1371/journal.pcbi.1003574

Interplay of Intrinsic and Synaptic Conductances in the Generation of High-Frequency Oscillations in Interneuronal Networks with Irregular Spiking

Figure 5

Effects of membrane potential depolarization and coupling on network dynamics.

A: Membrane potential distributions of GIF and r-matched IF neurons in response to the background input alone, for different values of the background inhibition-to-excitation ratio k. In all cases, the voltage threshold for spike generation has been adjusted in order to match the rate response of the canonical GIF (73.7 Hz). Color and line style code as indicated. Inset shows the mean membrane potential as a function of k for the four model networks shown in Figure 3 (same line colors and styles). B, D: Synchrony (as assessed by , B) and firing rates (D) as a function of coupling strength . C: Enlarged view of B for low values of coupling strength. E: Ratio between corresponding curves in C. Solid lines show ratios between canonical models ((GIF)/(IF)), while dashed lines show ratios between models that have been adjusted in order to exhibit the same rate response to the background input (purple, blue and light blue, (GIF)/(r-matched IF); brown, red and orange, (r-matched GIF)/(IF)). Dots in B–E indicate simulated points, lines are drawn to guide the eye.

doi: https://doi.org/10.1371/journal.pcbi.1003574.g005