Coupling of Lever Arm Swing and Biased Brownian Motion in Actomyosin
Figure 6
Monte Carlo simulation of a combined process of diffusion of myosin head along landscapes and transitions among landscapes.
(A) Two example trajectories of myosin movement. Trajectories starting from the A.Mpre.ADP.Pi state and ending in the A. Mrigor state (left), and their close-up from A.Mclosed to A.Mrigor (right). Horizontal mesh lines are drawn every 5.5 nm. (B) The distribution of displacement of myosin head after the system reaches the A.Mclosed state. 8,000 trajectories starting from random positions in the A.Mpre.ADP.Pi state were used to calculate the distribution.