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Bistable Dynamics Underlying Excitability of Ion Homeostasis in Neuron Models

Figure 4

Projection of the trajectories corresponding to Fig. 1a and Fig. 3a.

The shaded regions indicate unphysiological –combinations that imply negative (lower left region) or negative (upper region in left plot). Stable and unstable fixed points are marked by solid and open circles. (a) In the bistable case an initial stimulation (dashed line) leads to large subsequent changes in ion concentrations that terminate in the second fixed point of the system. (b) The excitable motion starts very similar to case (a), but after reaching the extremal concentration values the system slowly returns to its initial state.

doi: https://doi.org/10.1371/journal.pcbi.1003551.g004