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Bistable Dynamics Underlying Excitability of Ion Homeostasis in Neuron Models

Figure 3

Upper panels: Membrane and Nernst potentials, lower panel: Ion concentrations vs time.

(a) Stimulation with the same, but earlier applied, current pulse as in Fig. 1(a). Due to the additional potassium regulation the system returns to the physiological equilibrium after an approximately 60 sec lasting FES and subsequent hyperpolarization. (b) Similar dynamics as in (a) is observed for a temporary pump switch–off like in Fig. 1(b).

Figure 3

doi: https://doi.org/10.1371/journal.pcbi.1003551.g003