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Bistable Dynamics Underlying Excitability of Ion Homeostasis in Neuron Models

Figure 2

Bifurcation diagram of the ion–based model.

Bifurcations are marked by red circles, the physiological equilibrium by a green square. Following the z–shaped fixed point characteristic from below there are two saddle–node bifurcations (limit point, LP) at and , and three subcritical Hopf bifurcations (HB) at , and . The limit cycles created in HB1, HB2 and HB3 disappear in homoclinic bifurcations (HOM) at , and , respectively. The second LP and the second HB together with the HOM of limit cycles occur in a very narrow parameter range (see blow–up inset). The number of stable () and unstable () directions of the fixed point is indicated by the –tuples. There is bistability of a physiological state and a depolarized state with largely reduced ion concentration gradients between and .

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1003551.g002