Multiple Model-Informed Open-Loop Control of Uncertain Intracellular Signaling Dynamics
Figure 4
Summary of target tracking performances for the simulated case studies.
(A) Summary of experiments involving realistic control reagents sanguinarine and U0126. (B) Summary of experiments involving hypothetical reagents aZAP and iZAP. Target tracking performance is measured by the squared error between target profiles and controlled plants. Data shown are mean ± standard error between matched (Sm, n = 30) and mismatched (Smis, n = 60) single-model controllers, Meq (n = 30) and Maw (n = 30). Group letters denote statistically significant differences between groups (p<0.05) as calculated by one-way ANOVA with Tukey multiple comparisons test (SigmaStat v3.5, Systat Software, Inc).