Multiple Model-Informed Open-Loop Control of Uncertain Intracellular Signaling Dynamics
Figure 1
Generalized illustration of the TCR-mediated signaling pathway through the Erk-MAPK cascade.
Arrow- and diamond-heads denote activation and inhibition of substrate molecules, respectively. TCR stimulation is achieved through αCD3 (green) binding. Subsequent Erk activation (black) controlled using small molecule inhibitors sanguinarine (blue) and U0126 (red).