Exact Hybrid Particle/Population Simulation of Rule-Based Models of Biochemical Systems
Figure 10
Memory use vs. simulated volume for different simulation methods, including a hypothetical automated HPP (aHPP).
For finite networks, aHPP memory use plateaus once the entire reaction network has been generated. For infinite networks, the scaling at large volumes should fall somewhere between constant and linear (no worse than HPP) depending on the model (see Sec. S2 of Text S1 for an analysis).