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Exact Hybrid Particle/Population Simulation of Rule-Based Models of Biochemical Systems
Figure 7
HPP performance analysis for the 
signaling model.
(A) peak memory usage (left: absolute, right: relative to NFsim); (B) CPU run time (left: absolute, right: relative to NFsim); (C) number of reaction events fired during a simulation (
); (D) timecourses (means and 
frequency envelopes; 
) for 
receptor (top) and receptor-recruited, 
Syk (bottom). The slight deviation from linearity for ‘NF’ in (A) is an artifact of how memory is allocated in NFsim. SSA timecourses are virtually indistinguishable from those in (D) and have been omitted for clarity.
doi: https://doi.org/10.1371/journal.pcbi.1003544.g007