Phylogenetic Quantification of Intra-tumour Heterogeneity

doi:10.1371/journal.pcbi.1003535

Phylogenetic Quantification of Intra-tumour Heterogeneity

Figure 3

Efficient distance calculation is enabled via a transducer architecture.

A) Overlapping genomic rearrangements modify the associated copy-number profiles in different ways. Amplifications are indicated in green, deletions in red. The blue rectangles indicate the previous event. B) The one-step minimum event transducer describes all possible edit operations achievable in one event. This FST is composed times with itself to create the the full minimum event FST . Edge labels consist of an input symbol, a colon and the corresponding output symbol, followed by a slash and the weight associated with taking that transition. C) The minimum event FST is asymmetric and describes the evolution of a genomic profile from its ancestor. Composed with its inverse this yields the symmetric minimum event distance .

doi: https://doi.org/10.1371/journal.pcbi.1003535.g003