Phylogenetic Quantification of Intra-tumour Heterogeneity
Figure 1
Evolutionary copy-number trees are reconstructed in three steps.
1) After segmentation and compression, major and minor alleles are phased using the minimum event criterion. 2) The tree topology is reconstructed from the pairwise distances between genomes. 3) Reconstruction of ancestral genomes yields the final branch lengths of the tree, which correspond to the number of events between genomes.