Biophysical Properties of Intrinsically Disordered p130Cas Substrate Domain — Implication in Mechanosensing
Figure 10
LIM pair binding peptides and spacer regions.
Simple hypothetical model of a LIM domain pair (shown in green and purple ribbon diagram) bound to CasSD shown in yellow with its secondary structural elements colored in red. Wavy red lines and red arrows represent PPII helices and β-strands, respectively. Hydrogen bonds between LIM domains and CasSD are depicted in blue dotted lines. Mechanical stretching force is represented by gray arrows.