Global Quantitative Modeling of Chromatin Factor Interactions
Figure 2
Maximum entropy model accurately predicts high-order chromatin factor pattern frequencies in the data.
For evaluation we predicted frequencies of chromatin factor combinatorial binding patterns each involving either randomly selected 10 chromatin factors (A) or all 73 chromatin factors (B) from model, and compared against observed frequencies in test set data. Red dots represent estimations from maximum entropy model with up to 3rd order interactions learned with regularization and fine-tuning; gray dots show estimations from independent Bernoulli model. Independent Bernoulli model assumes independence between occurrences of different chromatin factors. The diagonal line is the identity line.