Computational Analyses of Synergism in Small Molecular Network Motifs
Figure 7
Summary of the degrees of NB and additive synergism observed for all motifs for S = 1 and S = 10.
Degrees of synergism are plotted for kdA/kdB (A), kdA/kST (B), and kdA/KT (C). Motif abbreviations are as in Fig. 1. Vertical dashed lines delineate each motif and its associated synergism degrees (four for each combination of a motif and a parameter pair). For each motif and parameter pair, the degrees of additive synergism are plotted as blue and light green bars, and the degrees of additive synergism are plotted as black and grey bars, for S = 1 and S = 10 respectively. Negative values represent degrees of antagonism. In a few cases, the NB and AE curves were intertwined (e.g., Fig. S1B1) and exhibited both additive synergism and additive antagonism. For those cases only positive values (synergism) are plotted. The values of some data are too small to be easily visualized.