Computational Analyses of Synergism in Small Molecular Network Motifs
Figure 4
For Variant M (S = 1), the histograms of synergism degrees from 91 parameter pairs were compared between standard parameter values and varied parameter values.
(A) The stimulus and response curves of A (see Eq. 1) and B (see Eq. 2) with standard parameter values (A1) and with parameters altered to give slower B dynamics (orange trace), or delayed B dynamics (green trace), with dynamics of A unchanged (black trace) (A2). (B) The histograms of NB synergism (B1) and additive synergism (B2) degrees with standard parameter values (grey bars) and with parameters altered to give slower B dynamics (orange bars) or delayed B dynamics (green bars). (C) The histograms of NB synergism (C1) and additive synergism (C2) degrees with standard parameter values (grey bars), with kST increased by 25% (red bars), and with kST reduced by 25% (pink bars). (D) The histograms of NB synergism (D1) and additive synergism (D2) degrees with standard values (grey bars), KT increased by 25% (dark brown bars), and KT reduced by 25% (light brown bars).