Computational Analyses of Synergism in Small Molecular Network Motifs
Figure 3
Histograms of NB synergism (A) and additive synergism (B) degrees from 91 parameter pairs for Variant M (grey bars) and Variant A (green bars) (S = 1).
(C) Variation of the parameter pair KTA/kbasal_A in Variant M shows that additive synergism can exist in the absence of NB synergism. kbasal_A increases from 0 to 90% as KTA concurrently decreases from 90 to 0%. (D) Variation of KB/KT in Variant A shows that NB synergism can exist in the absence of additive synergism (red box, concave-down NB curve is below AE curve).