Computational Analyses of Synergism in Small Molecular Network Motifs
Figure 2
A schematic of NB synergism (A) and additive synergism (B).
Response for AE curve = effect of drug 1 alone+effect of drug 2 alone. The maximal difference between peak value and endpoints of NB curves determines the maximum NB synergism. The maximal difference between NB and AE curves determines maximum additive synergism.