Computational Analyses of Synergism in Small Molecular Network Motifs
Figure 1
Canonical model and variations.
(A1) The canonical model describes the convergence of two signaling pathways (elements A and B) onto target (T). A single stimulus (S) activates both A and B. Then, A and B positively regulate the activation of T. (A2) For the canonical model, the stimulus-response curves are transient in both model variants M and A (S = 1). (B–E) Various network motifs derived from the canonical model. (B1) Two types of coherent feed-forward loop (FFL). (B2) Positive feed-back loop between A and B (i.e., mutual excitation, ME). (B3) Negative feed-back loop between A and B (i.e., mutual inhibition, MI). (C1) Positive auto-regulation loop of A (i.e., auto-excitation, AE). (C2) Negative auto-regulation loop of A (i.e., auto-inhibition, AI). (D1) Negative feedback between A and B (NF (B-A)). (D2) Negative feedback from T to A and B (NF (T-A/B)). (E) Positive feedback from T to A and B (PF (T-A/B)).