Long Non-Coding RNA and Alternative Splicing Modulations in Parkinson's Leukocytes Identified by RNA Sequencing
Figure 6
Network analysis identifies disease and treatment-relevant biological pathways.
Network analysis of disease-relevant pathways identified disease involved processes. The network analysis was conducted on genes identified as undergoing splicing changes through ASPIRE analysis of both junctions and exons read counts. The analysis identified disease-modified biological processes included ATP processing, nuclear transport and immune-related events. The network was constructed using the ClueGO Cytoscape plug-in using KappaScore grouping, yielding 40 Gene Ontology (GO) terms functionally organized with 183 connections. Larger nodes (circles) indicate larger connectivity. Thicker edges marks higher statistical significance. The different functional groups are marked with different colors.