An In-Silico Model of Lipoprotein Metabolism and Kinetics for the Evaluation of Targets and Biomarkers in the Reverse Cholesterol Transport Pathway
Figure 9
Model predictions for the dependence of HDL measures (HDL-C, panel A; ApoA-I, panel B; HDL size, panel C; HDL particle concentration, panel D; lipid-poor ApoA-I, panel E) and RCT (panel F) on the CETP level.
The model simulation curves were obtained by decreasing the 3 parameters associated with CETP activity from 100% to 0% of those corresponding to the nominal subject. For each prediction, the mean and the 95% confidence intervals are plotted.