An In-Silico Model of Lipoprotein Metabolism and Kinetics for the Evaluation of Targets and Biomarkers in the Reverse Cholesterol Transport Pathway
Figure 2
The fit of the model to the calibration data for CETP deficiency: HDL-C (panel A), ApoA-I (panel B), LDL-CE (panel C) and VLDL-CE (panel D).
The data are as shown in Table 6, obtained by pooling HDL-C and ApoA-I data from references [81]–[83] and LDL-CE, VLDL-CE data from references [20], [21]. The model simulation curves were obtained by decreasing the 3 parameters representing CETP activity from 100% to 0% of those corresponding to the nominal subject.