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Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver

Figure 10

Results for the metabolization of spiramycin and comparison to experimental data from an isolated perfused liver.

The plot shows the outflow rates of spiramycin from our single pass perfusion model for a spiramycin inflow during minutes compared to experimental data from an isolated perfused liver [32]. While the experimental values were measured in a healthy liver, we also show simulation results for the steatotic states. The volume renderings show the total spiramycin concentration for four time points after the end of the inflow ( minutes).

doi: https://doi.org/10.1371/journal.pcbi.1003499.g010