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Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver

Figure 9

Simulations with a spatially resolved model for midazolam.

The large plot (left) shows the outflowing midazolam concentrations for the healthy state and the pathological states for a midazolam inflow during seconds. For comparison, results for simulations with a PBPK model are shown as well. The four smaller plots (right) show the total amounts contained in the subspaces of the liver, using the same lines and colors. Here, a difference between healthy and pathological states can be observed. In case of -induced necrosis, higher outflow concentrations are predicted whereas they are lower in the steatotic cases. In particular, the outflow concentration as well as the amounts contained in the plasma and the interstitium also show a difference of up to , , and percent, respectively, between the homogeneous and heterogeneous steatotic states (marked by arrows).

doi: https://doi.org/10.1371/journal.pcbi.1003499.g009