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Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver

Figure 5

PBPK model establishment and parameter identification.

Pharmacokinetic simulations of an intravenous dose of midazolam of per kg body weight (left) and an oral dose of spiramycin of per kg body weight (right) are shown. The PBPK simulations (red lines) were compared to experimental data (green asterisks) for midazolam [66] and spiramycin [67] in mice.

doi: https://doi.org/10.1371/journal.pcbi.1003499.g005