Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver
Figure 4
Visualization of pathophysiological states (steatosis, -induced necrosis) in the spatially resolved liver model.
The images show the distribution of lipid in our steatotic model with homogeneous lipid accumulation throughout the whole liver (a, b) and different heterogeneous distributions (c, d) in the left lateral lobe and the remaining lobes. The average lipid accumulation over the whole liver is the same in both steatosis cases. The lipid accumulation is assumed to change the distribution and metabolization behavior according to Equation 9. The liver volume affected by -induced necrosis is shown in dark at the bottom (e, f). In each case, a volume rendering (a, c, e) and one coronal slice through the model liver (b, d, f) is shown along with the vascular structures.