Model-Based Analysis for Qualitative Data: An Application in Drosophila Germline Stem Cell Regulation
Figure 1
Drosophila germarium system and data.
A) Diagram of Wild Type germarium structure with anterior to the left, showing cap cells (CC), germline stem cells (GSC), cystoblasts (CB), and cysts. Below, a color-matched schematic of the 1 dimensional model used in this study. B) Diagram of signaling in the anterior germarium, showing the internal regulatory state of the GSC (left), and CB (right). Yellow and blue boxes refer to differentiation- and self-renewal-promoting elements, respectively. C) Examples of typical images (upper) and qualitative interpretations (lower) comprising available data. Qualitative interpretations are mappings of relative intensity (fluorescent, colorimetric, etc.) and original author interpretations to the 1-D model, indicated at bottom. Relevant color channels per image are (from left to right): pMad in red, Nos in red, Bam in green, Phenotype showing spectrosomes in red. Images reproduced/adapted from [57] (1st from left), [58] (2nd and 3rd from left), and [59] (right).