< Back to Article
Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence
Figure 6
Effect of inhibitory coupling strength
on the control of absence seizures by the SNr-TRN and SNr-SRN pathways. Tow-dimensional state analysis (A) and corresponding frequency analysis (B) in the (
) panel for different values of 
. Here only three dynamical state regions are observed in (A): the SWD oscillation region (II), the simple oscillation region (III) and the low firing region (IV). In (A1)–(A4), the regions marked by red diamonds denote the whole suppression regions of SWDs, the white dashed lines represent the boundaries of suppression regions, and the red dashed lines stand for the demarcations between the bidirectional (double arrow) and unidirectional (single arrow) suppression regions. In (B1)–(B4), the yellow asterisk regions surrounded by black dashed lines denote the typical 2–4 Hz SWD oscillation regions. From left to right, the strengths of inhibitory projections from the TRN to SRN are: 
(A1, B1), 
(A2, B2), 
(A3, B3), and 
(A4, B4), respectively. For better showing and comparing the bidirectional suppression regions among different subfigures, here we mainly consider the scale factor for all values of 
within the same and small interval from 0 to 1. As an additional comparison, both the state analysis and frequency analysis for 
in a relatively larger 
interval is given in Fig. S2.
doi: https://doi.org/10.1371/journal.pcbi.1003495.g006