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Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence
Figure 3
Control of absence seizures by the isolated SNr-TRN pathway.
A, B: The state analysis (A) and frequency analysis (B) in the (
) panel. Here 
is the inhibitory coupling strength of the TRN-SRN pathway, whereas 
is the excitatory coupling strength of the STN-SNr pathway. Different colors in (A) represent different dynamical state regions: the saturation region (I), the SWD oscillation region (II), the simple oscillation region (III) and the low firing region (IV). The suppression of SWDs appears to the right of the white dashed line in (A), where the white down arrow indicates that the SWD oscillation can be inhibited by decreasing 
. The yellow asterisk region surrounded by black dashed lines in (B) denotes the typical 2–4 Hz SWD oscillation region. C, D: Bifurcation diagrams of 
as a function of 
for different 
. The strengths of the inhibitory projections from the TRN to SRN are set as 
(C) and 
(D), respectively. Different colors in (C) and (D) represent different dynamical state regions, corresponding to those in phase diagram (A). E: The mean firing rates (MFRs) of several key neural populations as a function of 
, with 
. Here four neural populations are considered: SNr (blue dot), excitatory pyramidal neurons (green asterisk), SRN (black circle) and TRN (red square). Two black dashed lines in (E) represent the occurring positions of the low and high triggering mean firing rates (TMFRs), respectively. F: The low (red filled circle) and high (green filled square) TMFRs as a function of 
. For all simulations, the SNr-SRN pathway is artificially blocked (i.e., 
).
doi: https://doi.org/10.1371/journal.pcbi.1003495.g003