Bidirectional Control of Absence Seizures by the Basal Ganglia: A Computational Evidence
Figure 1
Framework of the basal ganglia-corticothalamic network.
Neural populations include excitatory pyramidal neurons (EPN);
inhibitory interneurons (IIN);
thalamic reticular nucleus (TRN);
specific relay nuclei (SRN);
striatal D1 neurons;
striatal D2 neurons;
substantia nigra pars reticulata (SNr);
globus pallidus external (GPe) segment;
subthalamic nucleus (STN). Note that we do not model the globus pallidus internal (GPi) segment independently but consider SNr and GPi as a single structure in this work. Red lines with arrow heads denote the excitatory projections mediated by glutamate receptors. Blue solid and dashed lines with round heads represent the inhibitory projections mediated by GABAA and GABAB receptors, respectively. Compared with the traditional model of corticothalamic system on absence seizures, the basal ganglia are also included in our biophysical model.