Structural Insights into E. coli Porphobilinogen Deaminase during Synthesis and Exit of 1-Hydroxymethylbilane
Figure 2
Loop modeled structure of E.coli PBGD and its conserved residues in the active site.
A. The 3D coordinates of the E.coli PBGD were obtained from PDB (ID: 2YPN) and the missing loop region (42–60) was modeled using Modeller9v8. The same domain color scheme is followed throughout. B. Stereo view of the active site residues R11, D84, R131, R132, R149, R155, R176 and R232 along with conserved residues K55 and K59 (in green) and the DPM cofactor (in pink) shown as sticks.