Effect of Dedifferentiation on Time to Mutation Acquisition in Stem Cell-Driven Cancers
Figure 5
Exponential growth given varying stem cell population size and dedifferentiation.
Total number of stem cells (A, C, E) and corresponding final progenitor age distributions (B, D, F) are shown in black. Also shown are best exponential fits of the growth rate (blue) and our semi-analytic solution given by Eq. (18) (green). In all panels the probability of asymmetric stem cell division and the mean reversion parameter is
.