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Effect of Dedifferentiation on Time to Mutation Acquisition in Stem Cell-Driven Cancers

Figure 3

Times to fixation without dedifferentiation.

(A) Typical simulation trajectory for constant stem cell population size and mutation rate . The numbers of zero-, one-, and two-mutation stem cells are shown in blue, red, and green, respectively. The proportion of two-mutation cells in the progenitor population is shown in black. (B) Times to fixation for constant and variable stem cell population size models. Histograms of waiting times to fixation of two-mutation cells for constant (blue) and variable stem cell population size with high fluctuations (green, ) and low fluctuations (red, ). The semi-analytic distribution of waiting times calculated from Eq. (12) is shown in black. In both panels the mutation rate .

doi: https://doi.org/10.1371/journal.pcbi.1003481.g003