Effect of Dedifferentiation on Time to Mutation Acquisition in Stem Cell-Driven Cancers
Figure 2
Steady-state progenitor distributions in the absence of stem cell mutation.
(A, B) Fraction of two-mutation cells as a function of mutation rate and proliferative advantage
for (A) unlimited growth, (B) logistic growth for each subpopulation. (C, D): Corresponding total population sizes for (C) unlimited growth, (D) logistic growth. Birth/death rates of progenitor cells are given by Eq. (5) with constant death rate
and sigmoidal birth rate with maximal growth rate
,
for
. In (B) the carrying capacity used is
Other parameters are as in Table 1. For two-mutation cells to reach appreciable levels in this scenario, both the mutation rate and the proliferative advantage must be unreasonably large.