The Structural Pathway of Interleukin 1 (IL-1) Initiated Signaling Reveals Mechanisms of Oncogenic Mutations and SNPs in Inflammation and Cancer
Figure 6
SNPs/mutations mapped on the predicted complex of IL-1α with IL1R1.
IL1A (Interleukin 1 alpha) – IL1R1 (Interleukin 1 type I receptor) complex: Ile 68 (p.Ile68Asn SNP) is on the interface as a computational hot spot residue* and Ile276 (p.Ile276Thr mutation - endometrioid carcinoma) is a nearby residue for the interface. Orange and blue balls: residue atoms related to the SNP and the mutation on IL1A and IL1R1, respectively.