Comparative Genome-Scale Reconstruction of Gapless Metabolic Networks for Present and Ancestral Species
Figure 1
Overview of the reconstruction method.
Genomes of target species are subjected to BLAST, GTG and InterProScan analyses to evaluate enzyme probabilities. Plausible gapless metabolic networks are assembled based on integrated enzyme evidence. Finally reconstructed models are converted into SBML and generic stoichiometric matrix formats.