The Free Energy Profile of Tubulin Straight-Bent Conformational Changes, with Implications for Microtubule Assembly and Drug Discovery
Figure 2
Crystal structure of the colchicine-bound soluble tubulin from the bovine tubulin:RB3-stathmin-like domain (SLD) (T2R) colchicine complex.
a) The T2R-colchicine complex is a head-to-tail longitudinal assembly of two αβ-tubulin heterodimers. b) 90° rotated view of the colchicine binding site. Figure was generated using PyMOL.