tRNA Signatures Reveal a Polyphyletic Origin of SAR11 Strains among Alphaproteobacteria
Figure 1
A universal schema for tRNA interaction networks.
tRNAs interact to varying degrees of specificity within a strongly conserved network of protein and RNA complexes. The simultaneous and conflicting requirements of “identity” and “conformity” on tRNAs create potential deleterious pleiotropic effects when components of the network mutate or are transferred to foreign cells by HGT. They also facilitate the bioinformatic prediction of Class-Informative Features (CIFs) from tRNAs that function together in the same or similar networks.