Correlation between Oncogenic Mutations and Parameter Sensitivity of the Apoptosis Pathway Model
Figure 8
Parameter sensitivity analysis and its correspondence with mutations in the extended pathway.
(A) The change in the saddle-node bifurcation point in response to a 20% increase or decrease of each parameter of the extended apoptosis pathway. Yellow and green bars indicate parameters that cause a large or small percentage change in the bifurcation points, respectively. (B) The change in the steady-state concentration of caspase-3 in response to a 20% increase or decrease in each parameter of the extended apoptosis pathway. Magenta and blue bars indicate parameters that cause a large or small change in the steady-state concentration of caspase3, respectively. (C) The correspondence between parameters linked to sensitivity of the bifurcation point (yellow bar) or caspase3 (blue bar) and high-frequency mutation genes. (D) The correspondence between insensitive parameters and low-frequency mutation genes. (E) The inconsistency between parameter sensitivity and gene mutation frequency. The numbers in the frame indicate the number of occurrences in the mutation spectrum of the gene that relates to the corresponding parameters.