Correlation between Oncogenic Mutations and Parameter Sensitivity of the Apoptosis Pathway Model
Figure 3
Bifurcation diagram for nuclear p53 and caspase3 for apoptosis.
(A) The bifurcation diagram for nuclear p53 using DNA damage as the control parameter. (B) The bifurcation diagram for caspase3 using DNA damage as the control parameter (black dots). (C) Comparison of bifurcation point with an increase in the parameter kf5. Black, without increase; green, 1.9-fold increase; red, 4.2-fold increase.