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Correlation between Oncogenic Mutations and Parameter Sensitivity of the Apoptosis Pathway Model

Figure 2

The typical time evolution of the level of total nuclear p53 and caspase3.

Blue and black lines represent p53 concentrations at low- and high-level DNA damage, respectively; Green and red lines represent caspase-3 concentrations at low- and high-level DNA damage, respectively.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1003451.g002